Question 1

How much VRAM does open-instruct-human-mix-65b need?

Accepted Answer

open-instruct-human-mix-65b (65B) requires approximately 145.92485961914062 GB of VRAM at full precision (FP16), 73 GB at 8-bit quantization (Q8), and 36.5 GB at 4-bit quantization (Q4). The actual VRAM usage may be slightly higher due to KV cache and runtime overhead.

Question 2

What GPUs can run open-instruct-human-mix-65b?

Accepted Answer

We have 5 compatible GPUs indexed for open-instruct-human-mix-65b, including MI300X, B200, B100, MI325X, MI350X. Compatibility is determined by whether the GPU's VRAM can fit the model's memory footprint, potentially using quantization to reduce memory usage.

Question 3

What is the cheapest GPU to run open-instruct-human-mix-65b?

Accepted Answer

The cheapest GPU to run open-instruct-human-mix-65b in the cloud is the MI300X at $2.39/hr. Other affordable options include B200 ($6.79/hr). Prices reflect the lowest on-demand rate across cloud providers.

Question 4

Can open-instruct-human-mix-65b run on consumer hardware?

Accepted Answer

open-instruct-human-mix-65b requires approximately 145.92485961914062 GB of VRAM at FP16, and even with 4-bit quantization (Q4) it needs about 36.5 GB. This exceeds the 24 GB available on the highest-end consumer GPU (RTX 4090), so open-instruct-human-mix-65b requires datacenter or cloud GPUs.

Question 5

What quantization options are available for open-instruct-human-mix-65b?

Accepted Answer

open-instruct-human-mix-65b supports the following quantization levels: FP16 (full precision): ~145.92485961914062 GB, Q8 (8-bit): ~73 GB, Q6 (6-bit): ~54.7 GB, Q4 (4-bit): ~36.5 GB. Lower quantization reduces VRAM usage at the cost of some quality loss. Q8 offers a good balance between quality and memory savings, while Q4 provides maximum compression.

open-instruct-human-mix-65b

VRAM Requirements

Compatible GPUs

open-instruct-human-mix-65b FAQ

GPU	VRAM	Best Quant	From	Rent
MI300X	192 GB	FP16	$2.39/hr	Rent
B200	192 GB	FP16	$6.79/hr	Rent
B100	192 GB	FP16	—
MI325X	256 GB	FP16	—
MI350X	288 GB	FP16	—

VRAM requirements for open-instruct-human-mix-65b at different quantization levels
Quantization	VRAM Required
FP16	145.9 GB
Q8	73 GB
Q6	54.7 GB
Q4	36.5 GB